D & K combined for Bone, Vascular Health
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Consider Vitamin K!
Several vitamin K-dependent proteins serve essential roles in bone and cardiovascular health.⁴ Vitamin K1 and K2 are needed as cofactors to activate these proteins, which vitamin D promote.³ Vitamin K2 subtypes, menaquinone-4 (Mk-4) and menaquinone-7(Mk-7), are required for proteins involved in bone mineralization and preventing soft tissue calcification (e.g. arteries, kidneys), which essentially lowers the risk of fractures and coronary artery disease.³
Vitamin D & K Synergy
When supplementing vitamin D at doses needed to raise blood levels to an optimal range, it is prudent to include vitamin K2 as this combination has shown to improve bone mineral density, cardiovascular health, blood sugar stabilization and insulin sensitivity compared to vitamin D supplementation alone.³
Optimal Vitamin D Blood Levels
‡50-65 ng/mL : Adults
‡80-90 ng/mL : Autoimmune/Inflammatory Disorders
Optimal Vitamin K Blood Levels
0.2-3.2 nsg/mL, though impaired blood clotting
has been associated with levels below 0.5 ng/mL
Caution: Those taking a statin or bisphosphonate (osteoporosis medication) are at a higher risk of Vitamin K deficiency.
If someone is taking a blood thinner, they should seek medical advice from their doctor before beginning Vitamin K supplementation.
Summary of Physiological Roles in the Body
- Regulate calcium absorption and blood calcium levels
- Bone mineralization
- Immune function
- Inflammation modulation
- Neuromuscular function
- Cell growth modulation
- Modulation of key genes for physiologic processes
Vitamin D deficiency
impeded growth, bowing and softening of long bones, scoliosis, osteopenia/osteomalacia, autoimmunity, inflammation, insulin resistance, suppressed immune function, frequent upper respiratory tract infection, and cancer ¹⁻²
- Bone formation
- Blood clotting
- Arterial calcification prevention
- Glucose metabolism and insulin sensitivity regulation
- Optimizes sex hormones
Vitamin K deficiency
anemia, bruising, bleeding gums/nose,
heavy menses, osteoporosis,
coronary heart disease, aortic calcification
References: (1) academic.oup.com/jcem/article/96/7/1911/2833671 (2) academic.oup.com/edrv/article/33/3/456/2354950 (3) ncbi.nlm.nih.gov/pmc/articles/PMC5613455/ (4) ncbi.nlm.nih.gov/pmc/articles/PMC6059683/
Medical Disclaimer: This content is for informational and educational purposes only. It is not intended to provide medical advice or take the place of such advice or treatment from a personal physician. All readers/viewers of this content are advised to consult their doctor or qualified health professional regarding specific health questions. Neither BioSpec Nutritionals, Practitioner Supply nor the publisher of this content takes responsibility for possible health consequences of anyone reading or following the information in this educational content. All viewers of this content, especially those taking prescription or over-the-counter medications, should consult their physicians before beginning any nutrition, supplement or lifestyle program.
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