Probiotics and (GI) Gastrointestinal Health

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Why are probiotics and GI health so important?

Functional health essentially starts in the gut. Literally. The GI system is at the core of digestion, nutrient absorption, and removal of biological waste products. These are all vital functions that ALL systems throughout the body are dependent on. Consider the facts:

FACT  Imbalances in the GI tract can cause or contribute to considerable dysfunction and disease in virtually every major organ and organ system.

FACT  Systemic inflammation, pain disorders, immune dysregulation, poor cognition and mood, lack of energy, and cardiometabolic dysfunction may NEVER resolve without first improving GI health.

FACT  Dysbiosis, known as a disproportionate ratio of beneficial and harmful bacteria species in the GI tract, is one of the key factors related to GI dysfunction and systemic disease.

FACT  Specific conditions/diseases linked to dysbiosis include: Inflammatory Bowel Disease (IBD), Obesity, Allergic Disorders, Cardiovascular Disease, Diabetes, Autism, and Colorectal Cancer among others.

How Do Probiotics Improve GI Health?

  • Car Park Theory: Probiotics compete with harmful bacteria and microorganisms for limited space along the GI tract, much like a crowed parking lot, and thus block or disable pathogenic organisms.
  • Immune Cell Interaction: Probiotics can alter the activity of immune cells to decrease intestinal inflammation and systemic disease activity.
  • Intestinal Cell Health: Probiotics produce short chain fatty acids (SCFAs) and polyamines, which are needed to support the structure and function of intestinal cells.
  • Anti-inflammatory Activity: Probiotics can secrete metabolites that counteract inflammatory molecules, including cytokines, that drive disease processes.
  • Strengthen the Intestinal Barrier: Probiotics can increase mucin production, which offers a protective coating against harmful organisms and substances, and directly enhance structural proteins of the intestinal lining.

Which Probiotics Work Best?

ANSWER: It depends! Choosing the correct probiotics to improve GI health and other conditions can depend on many factors, and include:

  • The unique ratios and composition of innate bacteria in an individual.
  • The level of dysfunction or disease affecting an individual.
  • The coaction of probiotic strains and total probiotic counts.
  • The specific probiotic strain(s) provided in a formula. Strain specificity is key!

The goal is to minimize bad gut bacteria, and repopulate with specific strains of good gut bacteria for a well-balanced gut microbiome based on the needs of each individual.

The Heart Health Approach

Beyond Gut Health with Lactobacillus reuteri NCIMB 30242

Probiotic bacteria can do much more than improve gut health. The unique probiotic strain Lactobacillus reuteri NCIMB 30242 (LRC®) is supported by intensive clinical research for its effects on blood cholesterol levels.

How does it work?
LRC® supports healthy total cholesterol and LDL-cholesterol in two ways:

• Increases the body’s natural elimination of cholesterol
• Helps to maintain the normal amount of cholesterol produced in the body

LRC® accomplishes this by producing an enzyme called bile salt hydrolase that breaks apart bile acids. Bile acids are made by the liver to aid in the digestion of fatty acids and cholesterol. As bile acids are broken apart by LRC®, excess cholesterol is removed from circulation.

Benefits of LRC and Co-Q-10
Cardio-Biotic LRC includes Lactobacillus reuteri NCIMB 30242 combined with Co-Q-10 for added immune support. This combination yields a heart healthy probiotic formula with the following benefits:

️️♥️  Naturally supports total cholesterol already within the normal range*
♥️  Naturally supports LDL-cholesterol already within the normal range*
♥️  Supports the production of Vitamin D in the body
♥️  Supports healthy levels of hs-CRP and fibrinogen
♥️  Supports overall digestive health

Related resource: Blood Lab Biomarkers + glucose levels, homocystiene, Hb Ac1 levels

The Broad Spectrum Approach

Ultra Powerful Digestive and Immune Support

When a higher degree of gut dysbiosis is identified, a broad spectrum approach may be most effective to help balance the microbiome.

Probiotic strains from the genus Lactobacillus and Bifidobacterium are among the most recognized and commercially viable due to their efficacy and broad-spectrum benefits on human health. Studies of different Lactobacilli and Bifidobacteria strains have been performed in numerous human trials and animal models to investigate their immunomodulatory properties and potential to treat various infectious, allergic, and inflammatory conditions.

While clinical outcomes have shown to vary based on several factors, such as probiotic strain, dosage, condition treated, and characteristics of the host, strains of Lactobacilli and Bifidobacteria remain well-supported for their effects on digestive health, immune activity, and other specific conditions. Considering the variety of factors known to influence probiotic efficacy, formulas of higher potency and strain diversity may confer a more robust benefit across a wider range of conditions.

12 Strains

Ultra-Biotic 50 is the highest potency probiotic offered by BioSpec Nutritionals, containing 50 billion CFU per capsule/serving and 12 diverse strains belonging to the Lactobacilli or Bifidobacteria genera. It is considered safe for consumption by men and women of all ages.

The unique blend offers a combination of twelve specific strains shown clinically to support digestive and immune health, including:

The unique blend offers a combination of twelve specific strains shown clinically to support digestive and immune health, including:

1   Lactobacillus acidophilus UALa-01™7   Lactobacillus rhamnosus UALr-18™
2   Bifidobacterium lactis UABla-12™8   Bifidobacterium breve UABbr-11™
3   Lactobacillus plantarum UALp-05™9   Lactobacillus salivarius UALs-07™
4   Lactobacillus paracasei UALpc-04™10 Bifidobacterium bifidum UABb-10™
5   Lactobacillus casei UALc-03™11 Bifidobacterium longum UABl-14™
6   Lactobacillus brevis UALbr-02™12 Lactobacillus gasseri UALg-05™

The Specific Multi-Strain Approach

Powerful Digestive and Immune Support

In cases of identified digestive issues and disorders related to gut flora imbalances, it may prove more beneficial focus on targeted strains for a more specific multi-strain approach.

Normalize digestion and bowel movements
Named for its 15 billion CFUs, Probiotic-15 is a multi-species proprietary blend of 4 specific strains clinically proven to:

  • Reduce occasional digestive discomfort and support immune health.*
  • Normalize bowel habits and expedite recovery from occasional constipation.*
  • Aid in the healthy digestion of lactose.*

Strains you can count on!
While all probiotic strains included in BioSpec probiotic formulas show clinical efficacy and serve to normalize intestinal flora, Probiotic-5 is unique considering the reputation of the specific strains included.As the most senior and established formula among BioSpec probiotic offerings, Probiotic-5 includes strains with the greatest degree of evidence supporting efficacy across the widest range of conditions. Probiotic-5 was developed as a robust probiotic formula to improve conditions ranging from dysbiosis, to digestion, to allergies, or specific conditions like IBS.*Probiotic-5 provides 5 robust strains and a total of 5 billion CFUs per capsule. Probiotic-5 is our original formula, which remains unchanged since its introduction based on its high level of efficacy.

As a final word, the vast majority of probiotics, like those offered by BioSpec, are safe for most patient populations and age groups assuming immune function is not compromised. While a single probiotic formula or strain may be sufficient to improve a specific condition or imbalance, a combination of products and different strains may be necessary in cases of severe gut microbial imbalances. Ultimately, probiotics should serve a supportive role in combination with diet to repopulate the more permanent bacteria colonies developed from birth, that have been diminished as a result of poor diet, antibiotics, toxins, and other harmful lifestyle factors.

Related Resources & Links

» Gut Health, Dysbiosis & Disease – topic overview

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Support a Healthy Gut Microbiome


Choose from 4 Probiotic Products,
each formulated to suit varied needs of individual patients


Cardio-Biotic LRC
LRC® strain plus Co-Q-10
Heart-healthy approach with added immune support

Ultra-Biotic 50
12 strains/50 billion CFU
Broad-strain approach for cases of increased dysbiosis

4 strains/15 billion CFU
Normalize digestion and bowel movements

5 strains/5 billion CFU
Re-establish and balance gut flora


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Medical Disclaimer: This content is for informational and educational purposes only. It is not intended to provide medical advice or take the place of such advice or treatment from a personal physician. All readers/viewers of this content are advised to consult their doctor or qualified health professional regarding specific health questions. Neither BioSpec Nutritionals, Practitioner Supply nor the publisher of this content takes responsibility for possible health consequences of anyone reading or following the information in this educational content. All viewers of this content, especially those taking prescription or over-the-counter medications, should consult their physicians before beginning any nutrition, supplement or lifestyle program.

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